LITERATURE REVIEW

Mucoadhesive buccal tablets of Tizanidine

Abstract 1:

The study aim was involved with formulation and analysis of bioadhesive buccal drug delivery of tizanidine coordination compound tablets that is extensively metabolized by liver. The tablets were ready by direct compression mistreatment bioadhesive polymers like hydroxylpropyl methylcellulose K4M, metal cellulose alone, and a mixture of those 2 polymers. So as to enhance the permeation of drug, totally different permeation enhancers like beta-cyclodextrin (β-CD), hydroxylpropyl beta-cyclodextrin (HP-β-CD), and metal deoxycholate (SDC) were additional to the formulations. The β-CD and HP-β-CD were taken in 1:1 molar magnitude relation to drug in formulations. Bioadhesion strength, ex vivo duration, swelling, and in vitro dissolution studies and ex vivo permeation studies were performed. (10)

Abstract 2:

In the gift work mucoadhesive buccal tablets of Tizanidine coordination compound (TZD HCl) were ready by victimisation xanthan gum and in combination of xanthan gum with metal alginate as mucoadhesive polymers. Seven formulations were developed with variable concentrations of polymers. The ready tablets were evaluated for the load variation, thickness, hardness, friability, surface pH, swelling index, mucoadhesive strength and in vitro drug unharness. All the formulations displayed zero order unharnessed dynamics (‘r’ values from 0.9770 to 0.9944). Higuchi and Peppas knowledge reveals that the drug discharged by non-Fickian diffusion mechanism. (7)

Abstract 3:

The aim of this work was the planning Mucoadhesive bilayered buccal tablets of Tizanidine coordination compound (TZD HCl), victimization mucoadhesive polymers Carbopol 934(CP), HPMC K4M, HPMC K15M and atomic number 11 carboxymethylcellulose at the side of alkyl polyose as a rubberized backing layer. Preformulation studies of TZD HCl like compatibility studies with polymers, victimisation FTIR and DSC were applied. The bilayered buccal tablets were evaluated for weight variation, thickness, hardness, friability, surface pH, mucoadhesive strength, mucoadhesive time, swelling index, in vitro drug unleash and ex vivo permeation. FTIR and DSC found to be compatible with designated polymers. Bilayered buccal tablets containing CP and HPMC K4M within the magnitude relation 1:1 (BT1) had the most proportion of in vitro drug unleash in vi hours. The swelling index of the tablets hyperbolic with increasing amounts of CP. The optimized formulation (BT1) follows non-Fickian unleashes mechanism. (11)

Abstract 4:

In the present work mucoadhesive buccal tablets of Tizanidine hydrochloride (TZD HCl) were prepared by using guar gum and in combination of guar gum with sodium alginate as mucoadhesive polymers. Seven formulations were developed with varying concentrations of polymers. The prepared tablets were evaluated for the weight variation, thickness, hardness, and friability, surface pH, swelling index, mucoadhesive strength and in vitro drug release. All the formulations displayed zero order release kinetics (‘r’ values from 0.9770 to 0.9944). Higuchi and Peppas data reveals that the drug released by non-Fickian diffusion mechanism. The in vitro release parameter values (t50%, t70%, and t90%) displayed by the various formulations range from 1.84 to 5.86 h (t50%), 3.13 to 7.12 h (t70%) and 5.83 to 6.81 h (t90%). (7)